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| Reference | HORIZON-CL4-2025-01 |
| Publication date | 15 May 2025 EU Funding & Tenders Portal |
| Opening date | 22 May 2025 |
| Deadline date | 23 September 2025, 17:00 (CEST) |
| Programme | Horizon Europe Cluster |
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The chemical optimization support offered under this call covers:
- Searching structure/ activity landscape around validated primary hits in databases including patents to ensure novelty for the observed target-related or disease-model related activities
- Assessment of individual validated primary hits regarding their potential for directed chemical modification
- Recommendation of commercially available analogues for initial SAR characterization
- Chemical modifications of validated hits for improvement of specificity, activity and pharmacological properties
- Iterative re-screening of the respective biological assay for improved properties using chemically modified hits (done in close collaboration with the user and the respective EU-OPENSCREEN screening partner)